Infanrix-IPV


Manufacturer: GlaxoSmithKline Generic name: Diphtheria, tetanus, pertussis (acellular, component) and poliomyelitis (inactivated) vaccine (adsorbed) Infanrix-IPV Safety Safety assessment for Infanrix-IPV is based on studies done for its predecessor, Infanrix. The first was a small 335-infants study looking for pre-determined minor adverse events occurring within 3 days following vaccination. The study doesn’t tell us much because a) it was too small and b) most parents aren’t worried about short-term, minor side-effects. Two more studies in the US were of similar design and size but examined adverse reaction to Infanrix where this was used as a separate booster and not a primary course.[2] Slightly more serious side-effects were looked for during the Italian efficacy trial, such as high fever, persistent crying of more than 3 hours and seizures. But no placebo was used. Instead, the effects were compared to that of another type of vaccine, namely a whole-cell DTP vaccine, which is notorious for its adverse reactions and which was replaced for this reason. Not surprisingly, Infanrix was much safer than this other vaccine.[2] The only study which allowed for “unsolicited” adverse events, i.e. any side-effects and not just minor pre-selected ones, was the larger Germany study. [2] Unfortunately GlaxoSmithKline did not publish the full result in publicly available information and only gives some examples of minor events that happened within 7 days of any of the doses. I have searched the US VAERS database (which is for adverse reactions that happened after a vaccines has been put into use) for the relevant vaccine types from this manufacturer (including the types for Infanrix and Infanrix-IPV). Serious events included convulsion, vomiting, hypotonia, cyanosis, diarrhoea and many others, including coma and death. The data doesn’t necessarily mean that the vaccine was confirmed to be responsible, nor does it necessarily mean that these side-effects are…

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