Repevax


Manufacturer: Sanofi Pasteur MSD Generic name: Diphtheria, Tetanus, Pertussis (acellular, component) and Poliomyelitis (inactivated) Vaccine (adsorbed, reduced antigen content) Repevax Safety I have only been able to find very scant information about safety trials for Repevax. The manufacturer only disclosed that 390 children aged 3-6 received Repevax as a pre-school booster and that the side-effects listed further below in this chapter were found. Neither the UK, European nor US regulators had published any further information at the time of writing. The vaccine should not be used in pregnancy and is not meant to be used for primary immunisation. Repevax Efficacy The efficacy claim bases on immunogenicity/antibody response and the manufacturer says that almost everyone who received the vaccine as a booster developed the looked-for antibody levels when measured one month later. They also say they conducted a follow-up study which found that antibody levels were maintained after 5 years. No efficacy trial was done in the sense of finding out if vaccinated children are protected from illness but Sanofi Pasteur refers to a Swedish trial that showed protectiveness for a similar vaccine. This Swedish trial only looked into the Pertussis part of the vaccine and compared the protective effects of different pertussis vaccines against each other. There was no real placebo group. Whether the vaccine is effective or not therefore depends on whether immunogenicity really equals protection. Some studies suggest it does while others suggest it doesn’t. Further detail can be found in the relevant chapters for Diphtheria, Tetanus, Pertussis and Polio. Repevax Contraindications (according to the manufacturer) REPEVAX should not be administered to persons with known hypersensitivity to diphtheria, tetanus, pertussis or poliomyelitis vaccines to any other component of the vaccine (see Section 6.1) to any residual substances carried over from manufacture (formaldehyde, glutaraldehyde, streptomycin, neomycin, polymyxin B and…

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